Autoantibody Kits

Teprotest

The Teprotest kit was developed for the quantitative detection of antibodies to the human IGF1R (insulin-like growth factor 1 receptor, IGF-I receptor, CD221) in diluted serum samples.

The Teprotest kit is a 96-well immunoluminometric assay (ILMA) that uses a recombinant fusion protein consisting of the human IGF1R and a luciferase to detect antibodies to the human IGF1R bound to magnetic beads.

Product Specifications

Product name	Teprotest
Synonyms	IGF1R Autoantibody Test
Product code	TPT
Intended use	The Teprotest is designed for the quantitative measurement of IGF1R antibodies (IGF1R, ) in diluted serum samples.
Assay format	96 well microplate
Detection method	luminometric
Reactivity	Human
Sample volume*	5 – 10 µL
Sample type	Serum
Assay time	2 days
Assay sensitivity*	n. a.
Detection range*	n. a.
Quantification range*	n. a.
Kit storage	Refrigerated (2 – 8°C) and deep-frozen (< -65 °C)
Shelf life	6 months
Restrictions	For research use only.

* lot specific data

References:

Douglas RS, Kahaly GJ, Patel A, Sile S, Thompson EHZ, Perdok R, Fleming JC, Fowler BT, Marcocci C, Marinò M, Antonelli A, Dailey R, Harris GJ, Eckstein A, Schiffman J, Tang R, Nelson C, Salvi M, Wester S, Sherman JW, Vescio T, Holt RJ, Smith TJ. Teprotumumab for the Treatment of Active Thyroid Eye Disease. N Engl J Med. 2020 Jan 23;382(4):341-352. doi: 10.1056/NEJMoa1910434. PMID: 31971679.
Minich WB, Dehina N, Welsink T, Schwiebert C, Morgenthaler NG, Köhrle J, Eckstein A, Schomburg L. Autoantibodies to the IGF1 receptor in Graves’ orbitopathy. J Clin Endocrinol Metab. 2013 Feb;98(2):752-60. doi: 10.1210/jc.2012-1771. Epub 2012 Dec 21. PMID: 23264397.
Schwiebert C, Kühnen P, Becker NP, Welsink T, Keller T, Minich WB, Wiegand S, Schomburg L. Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength. Int J Mol Sci. 2020 Jan 11;21(2):463. doi: 10.3390/ijms21020463. PMID: 31940750; PMCID: PMC7013472.